NIH RFI: Neurodevelopmental Consequences of Substance Use Posted By: David Kennedy - Aug 1, 2014Tool/Resource: NITRC Community The following NIH Request for Information (RFI) may be of interest to the NITRC community: National Longitudinal Study of Neurodevelopmental Consequences of Substance Use - See more at: http://grants.nih.gov/grants/guide/notic... Response Date: August 31, 2014 Synposis/Purpose Terminology: For the purposes of this RFI, the term "substance" refers to the full spectrum of addictive substances including but not limited to nicotine, tobacco products, alcohol, cannabis, synthetic cannabinoids or cathinones, cocaine, and opiates. The term "substance use" refers broadly to experimentation, use, regular use, hazardous use, risky use, abuse, and compulsive use. While it is recognized that these concepts are not interchangeable, the term "substance use" is used throughout this RFI in order to capture the broad range of use that is relevant to this project. Substance-use disorders (SUDs) refer to clinical diagnoses defined in the Diagnostic and Statistical Manual of Mental Disorders V (DSM-5). Problem Statement: Preclinical research suggests that substance use affects the developing brain in profound and lasting ways, and cross-sectional comparisons of magnetic resonance imaging (MRI) data in humans indicate that substance use correlates with structural and functional brain abnormalities. However, no large prospective cohort study has been conducted to comprehensively assess the effects of substance use on human brain development and the resulting consequences. As substance-use policy in the United States continues to evolve, there is growing concern about increased access to and permissiveness around substance use, particularly marijuana and emerging tobacco products among youth. Therefore, the need to understand the effects of substance use on the human brain becomes more urgent than ever before. Fortunately, advances in neuroimaging provide an enormous capacity to better understand normal and atypical human brain development. The NIH is exploring optimal ways to configure a large longitudinal cohort study to prospectively examine the effects of substance use on the human brain during early adolescence into young adulthood. - See more at: http://grants.nih.gov/grants/guide/notic... |
| Latest News |
|